![]() White matter hyperintensities (WMHs) are areas of the hyperintense signal that are visible on T 2-weighted (T2w), T 2* proton density and fluid-attenuated inversion recovery (FLAIR) sequence MRI. Overall, our findings suggest that controlling high blood pressure and maintaining both a healthy body mass index and high levels of physical activity may reduce white matter hyperintensity load in older Indian adults, helping to prevent or delay dementia.ĭementia risk factors, MRI, white matter hyperintensities, cerebrovascular pathology, low- and middle-income countries Introduction We accounted for the possibility of reverse causality by additionally controlling for concurrent markers of neurodegeneration and cognitive impairment, with no substantial change in our findings. This model explained an additional 27% of the variance in white matter hyperintensity load (54 versus 27% for the baseline model with only age, sex and estimated total intracranial volume). A combined model of white matter hyperintensity load included five factors which were significant after multiple comparisons correction: systolic blood pressure, body mass index, urbanicity status (urban versus rural living), daily chore hours and the frequency of store trips. As a screening step, we estimated white matter hyperintensity load from fluid-attenuated inversion recovery MRI using a fully automated technique and tested for associations with each factor separately, controlling for age, sex and estimated total intracranial volume in each case. We investigated this question using cross-sectional MRI data ( n = 126) from a pilot neuroimaging sub-study of an ongoing, nationally representative epidemiological study of late-life cognition in India. ![]() However, little is currently known about how various socioeconomic, health, lifestyle and environmental factors affect the severity of these lesions, particularly in low- and middle-income countries such as India. While focal white matter hyperintensities are common among older individuals, extensive white matter hyperintensities have been found to accelerate the progression of dementia. The product can be downloaded as well freely from the author's website.White matter hyperintensities are areas of hyperintense signal on MRI that typically represent cerebrovascular pathology. The download manager is in no way affiliated or endorsed by the author of this product. During the download process we may show commercial offers, such as a toolbar or other browser add-ons. This download is managed by our ad-supported smart download manager. The Soft32 Downloader is not installed to the User’s computer, and the User must manually delete the Soft32 Downloader executable. The Soft32 Downloader launches the installation of the downloaded software products. In addition, if a sponsored software offer, like for example a toolbar, will be offered, it shall change the User’s home page, default search settings and 404-error traffic, in the event the User selects such options. When you run Soft32 Downloader, you implicitly accept the terms of use, privacy policy and EULA herein, and that you know about Soft32 Downloader. Soft32 Downloader is an executable Windows program that enables you to download computer programs, making the download process much faster and showing a progress bar. The program you want to download will be downloaded through the Soft32 Downloader.
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